중금속이 투여된 쥐에서 다양한 장기의 혈관 증가와 형태학적 변화에 대한 연구
Morphologic Alteration and Blood Vessel Increase By Heavy Metals in Mouse
김지선, 정휘, 김상우, 임원봉, 전상미, 최홍란, 김옥준,
소속 상세정보
김지선 ( Kim Ji-Sun ) - 전남대학교 치의학전문대학원 구강병리학교실
정휘 ( Zheng Hui ) - 전남대학교 치의학전문대학원 구강병리학교실
김상우 ( Kim Sang-Woo ) - 전남대학교 치의학전문대학원 구강병리학교실
임원봉 ( Lim Won-Bong ) - 전남대학교 치의학전문대학원 구강병리학교실
전상미 ( Jeon Sang-Mi ) - 전남대학교 치의학전문대학원 구강병리학교실
최홍란 ( Choi Hong-Ran ) - 전남대학교 치의학전문대학원 구강병리학교실
김옥준 ( Kim Ok-Joon ) - 전남대학교 치의학전문대학원 구강병리학교실
KMID : 0829220140380010001
Abstract
Heavy metals such as cadmium and mercury are a highly toxic metal that affects a variety of cellular events, such as cell proliferation, differentiation and survival in animals as well as in human. The exposed heavy metals significantly affected the development and health in pubertal period. However, it is not clear how the toxicity of heavy metals in pubertal affects comparing in adults. To determine the effects of heavy metals on pubertal and adults, heavy metals such as cadmium and mercury were exposed to in pubertal and adults mice for 48 and 72h. Results showed that mice exposed to heavy metals for several hours induced overall tissue and organ damage. Especially, blood vessels of the most organ were more increased in adult mice compared to pubertal mice. And for morphologic alteration, secretary organs such as salivary gland and kidney were affected the most. Taken together, exposing to heavy metal in mice altered the blood vessels. In addition, the adverse effects of cadmium and mercury were more severe in adult mouse than puberty mouse. Further study is needed to focus on endothelial cells for more precise its mechanism.
키워드
Blood vessel; Heavy metal
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